A web of regional organizations—diverse, dense, and storied—has long been active in Appalachia. These organizations are dedicated to addressing the full range of contemporary issues facing the region, including poverty, economic development, social justice, and the environment. The following organizations are currently serving the region.
- The Alliance for Appalachia
- Appalachia – Science in the Public Interest
- Appalachian Center for Economic Networks
- Appalachian College Association
- Appalachian Mountain Advocates
- Appalachian Regional Commission
- Appalachian Regional Development Initiative
- Appalachian Studies Association
- Appalachian Voices
- Brushy Fork Institute
- Center for Appalachian Studies
- Center for the Study of Ethnicity and Gender in Appalachia
- Central Appalachian Network
- Downstream Strategies
- Kentuckians for the Commonwealth
- Mountain Association for Community Economic Development
- Ohio Valley Environmental Coalition
- Southern Appalachian Forest Coalition
- Southern Appalachian Labor School
- Southern Appalachian Mountain Stewards
- Southern Poverty Law Center
- Statewide Organizing for Community Empowerment
- Virginia Organizing
- West Virginia Center on Budget and Policy
- West Virginia Highlands Conservancy
- West Virginia Solar United Neighborhoods (WV SUN)